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Ricin and Shiga Toxins: Pathogenesis, Immunity, Vaccines and Therapeutics by Nic

US $212.16
Approximately£159.34
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eBay item number:364697467573
Last updated on 29 Jan, 2025 00:15:44 GMTView all revisionsView all revisions

Item specifics

Condition
New: A new, unread, unused book in perfect condition with no missing or damaged pages. See the ...
ISBN-13
9783642274695
Book Title
Ricin and Shiga Toxins
ISBN
9783642274695

About this product

Product Identifiers

Publisher
Springer Berlin / Heidelberg
ISBN-10
3642274692
ISBN-13
9783642274695
eBay Product ID (ePID)
112018947

Product Key Features

Number of Pages
Xii, 276 Pages
Publication Name
Ricin and Shiga Toxins : Pathogenesis, Immunity, Vaccines and Therapeutics
Language
English
Publication Year
2012
Subject
Immunology, Pharmacology
Type
Textbook
Subject Area
Medical
Author
Nicholas Mantis
Series
Current Topics in Microbiology and Immunology Ser.
Format
Hardcover

Dimensions

Item Weight
21.2 Oz
Item Length
9.3 in
Item Width
6.1 in

Additional Product Features

Intended Audience
Scholarly & Professional
LCCN
2011-945111
Dewey Edition
23
Reviews
From the reviews:This 10-chapter volume is designed to take the reader through a series of well-written, well-illustrated reviews about ribosome inactivating proteins (RIPs). … this volume would give graduate biologists wishing to pick up information or ribotoxins a pretty good grounding in the current state of knowledge … . The volume is equally valuable for postgraduates interested in this field, in bringing them up to date with the state of play and likely research directions to come. (Gareth Griffiths, Microbiology Today, November, 2012), From the reviews: "This 10-chapter volume is designed to take the reader through a series of well-written, well-illustrated reviews about ribosome inactivating proteins (RIPs). ... this volume would give graduate biologists wishing to pick up information or ribotoxins a pretty good grounding in the current state of knowledge ... . The volume is equally valuable for postgraduates interested in this field, in bringing them up to date with the state of play and likely research directions to come." (Gareth Griffiths, Microbiology Today, November, 2012), From the reviews: This 10-chapter volume is designed to take the reader through a series of well-written, well-illustrated reviews about ribosome inactivating proteins (RIPs). … this volume would give graduate biologists wishing to pick up information or ribotoxins a pretty good grounding in the current state of knowledge … . The volume is equally valuable for postgraduates interested in this field, in bringing them up to date with the state of play and likely research directions to come. (Gareth Griffiths, Microbiology Today, November, 2012)
Series Volume Number
357
Number of Volumes
1 vol.
Illustrated
Yes
Dewey Decimal
615.95
Table Of Content
Preface.- Interaction of ricin and Stx with ribosomes and the sarcin-ricin loop.- How ricin and Stx enter and intoxicate mammalian cells.- Cellular stress response to Stx-ricin.- Ricin and Stx-Inflammation.- Pathogenesis of shiga-toxin producing E.coli.- Ricin and Stx-Interactions with the epithelium and intestinal mucosa.- Stx Pathogenesis-Kidney complications and renal failure.- Toxin-induced Apoptosis.- Small Molecule Inhibitors of Ricin and STX.- Antibody-mediated immunity to ricin.- Stx-animal models and immunotherapies.- Ricin- animal models and immunotherapies.- Ricin Vaccine Development.- Subject Index
Synopsis
Preface.- Interaction of ricin and Stx with ribosomes and the sarcin-ricin loop.- How ricin and Stx enter and intoxicate mammalian cells.- Cellular stress response to Stx-ricin.- Ricin and Stx-Inflammation.- Pathogenesis of shiga-toxin producing E.coli.- Ricin and Stx-Interactions with the epithelium and intestinal mucosa.- Stx Pathogenesis-Kidney complications and renal failure.- Toxin-induced Apoptosis.- Small Molecule Inhibitors of Ricin and STX.- Antibody-mediated immunity to ricin.- Stx-animal models and immunotherapies.- Ricin- animal models and immunotherapies.- Ricin Vaccine Development.- Subject Index., In May of 2011, Western Europe experienced a severe outbreak of Shiga toxin (Stx)-producing E. coli (STEC) that culminated in more than 3200 cases and 39 deaths. While Stx is not the only virulence factor associated with STEC, it is certainly the primary determinant associated with the onset of hemolytic uremic syndrome (HUS). At the present time, there are no clinically approved measures to neutralize Stx in individuals suffering from STEC infection. Nor are there any preventatives or therapeutics for ricin toxin. Although incidents of ricin exposure are largely unheard of, federal agencies and public health officials consider it a significant threat. It is well documented that domestic and international terrorist groups have stockpiled, and in some cases weaponized ricin with the intent of releasing it into the public sphere and causing panic, illness and/or death on a local, regional, or possibly national scale. The chapters, written by leading experts in the field, are organized so as to cover all aspects of ricin and Stx, including pathogenesis, immunity, vaccines and therapeutics. This outstanding collection of reviews will serve as an important and readily accessible resource for the research community in the coming years.
LC Classification Number
RM300-666

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