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MAP Kinase Signaling Protocols by Rony Seger (English) Paperback Book
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Item specifics
- Condition
- ISBN-13
- 9781493961054
- Type
- NA
- Publication Name
- NA
- ISBN
- 9781493961054
About this product
Product Identifiers
Publisher
Humana Press
ISBN-10
1493961055
ISBN-13
9781493961054
eBay Product ID (ePID)
248444298
Product Key Features
Edition
2
Book Title
Map Kinase Signaling Protocols
Number of Pages
Xiv, 529 Pages
Language
English
Topic
Life Sciences / Cell Biology
Publication Year
2016
Illustrator
Yes
Genre
Science
Book Series
Methods in Molecular Biology Ser.
Format
Trade Paperback
Dimensions
Item Weight
48.9 Oz
Item Length
10 in
Item Width
7 in
Additional Product Features
Dewey Edition
22
Series Volume Number
661
Number of Volumes
1 vol.
Dewey Decimal
572.76
Table Of Content
Activation and Function of Components of the MAP Kinase Signaling Cascades.- The MAP Kinase Signaling Cascades: A System of Hundreds of Components Regulates a Diverse Array of Physiological Functions.- Determination of ERK Activity: Anti-phospho-ERK Antibodies and In Vitro Phosphorylation.- Activation of SAPK/JNKs In Vitro.- Activation of p38 and Determination of Its Activity.- Activity Assays for Extracellular Signal-Regulated Kinase 5.- Use of Inhibitors in the Study of MAP Kinases.- Study of MAP Kinase Cascades as Transmitters of Membranal Receptor Signals.- MAP Kinase Activation by Receptor Tyrosine Kinases: In Control of Cell Migration.- Activation of Ras and Rho GTPases and MAP Kinases by G-Protein-Coupled Receptors.- Regulation of MAP Kinase Signaling by Calcium.- Identification of Novel Substrates of MAP Kinase Cascades Using Bioengineered Kinases that Uniquely Utilize Analogs of ATP to Phosphorylate Substrates.- ERK-MAP Kinase Signaling in the Cytoplasm.- Lentiviral Vectors to Study the Differential Function of ERK1 and ERK2 MAP Kinases.- Structure-Function Relationships and Localization of MAP Kinases.- Structural Studies of MAP Kinase Cascade Components.- Analysis of MAP Kinases by Hydrogen Exchange Mass Spectrometry.- A "Molecular Evolution" Approach for Isolation of Intrinsically Active (MEK-Independent) MAP Kinases.- Reconstitution of the Nuclear Transport of the MAP Kinase ERK2.- Localization and Trafficking of Fluorescently Tagged ERK1 and ERK2.- Studies on the Regulation of MAP Kinase Cascades.- Studying the Regulation of MAP Kinase by MAP Kinase Phosphatases In Vitro and in Cell Systems.- Proteomic Analysis of Scaffold Proteins in the ERK Cascade.- Analysis of ERKs' Dimerization by Electrophoresis.- MAP Kinase: SUMO Pathway Interactions.-Computational Modelling of Kinase Signalling Cascades.- Use of Lower Organisms, Animal Models, and Human Genetics in the Study of MAP Kinases.- Analysis of Mitogen-Activated Protein Kinase Activity in Yeast.- Detection of RTK Pathway Activation in Drosophila Using Anti-dpERK Immunofluorescence Staining.- Studying MAP Kinase Pathways During Early Development of Xenopus laevis.- Deciphering Signaling Pathways In Vivo: The Ras/Raf/Mek/Erk Cascade.- Mutational and Functional Analysis in Human Ras/MAP Kinase Genetic Syndromes.- Study of MAP Kinases in Specific Physiological Systems.- Implication of the ERK Pathway on the Post-transcriptional Regulation of VEGF mRNA Stability.- Studies on MAP Kinase Signaling in the Immune System.- Methods to Study MAP Kinase Signalling in the Central Nervous System.- MAP Kinase Regulation of the Mitotic Spindle Checkpoint.- Using High-Content Microscopy to Study Gonadotrophin-Releasing Hormone Regulation of ERK.
Synopsis
Exploring the activation and function of components of the MAPK signaling cascades, this volume presents fully updated techniques to study MAPK. Chapters include lists of the necessary materials, step-by-step laboratory protocols, and tips on troubleshooting and avoiding known pitfalls., Mitogen-activated protein (MAP) kinase (MAPK) cascades are key signaling components that govern essentially all cellular processes evoked by any type of stimulation, and it has been well established that the malfunctioning of these cascades leads to various diseases including cancer, autoimmunity, and diabetes. In MAP Kinase Signaling Protocols, Second Edition, expert researchers fully update the popular first edition the key techniques used in the study of MAPK signaling cascades in various cellular contexts. This thorough volume explores essential topics such as activation and function of components of the MAPK signaling cascades, the study of MAPK cascades as transmitters of membranal receptor signals, structure-function relationships of MAPKs, studies on the regulation of MAPK cascades, the use of lower organisms, animal models, and human genetics in the study of MAPKs, as well as the study of MAPKs in specific systems and diseases. Written in the highly successful Methods in Molecular Biology(tm) series format, chapters includes introductions to their respective subjects, lists of the necessary materials, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Comprehensive and cutting-edge, MAP Kinase Signaling Protocols, Second Edition aims to facilitate the study of MAPKs and allow for quicker progress in our knowledge of many vital cellular processes as well as devastating diseases., Part I: Activation and Function of Components of the MAP Kinase Signaling Cascades 1. The MAP Kinase Signaling Cascades: A System of Hundreds of Components Regulates a Diverse Array of Physiological Functions Yonat Keshet and Rony Seger 2. Determination of ERK Activity: Anti-Phospho-ERK Antibodies and In vitro Phosphorylation Shiri Procaccia, Sarah Kraus, and Rony Seger 3. Activation of SAPK/JNKs In vitro Deborah N. Chadee and John M. Kyriakis 4. Activation of p38 and Determination of Its Activity Huamin Zhou, Jianming Chen, and Jiahuai Han 5. Activity Assays for Extracellular Signal-Regulated Kinase 5 Kazuhiro Nakamura and Gary L. Johnson 6. Use of Inhibitors in the Study of MAP Kinases Kimberly Burkhard and Paul Shapiro Part II: Study of MAP Kinase Cascades as Transmitters of Membranal Receptor Signals 7. MAP Kinase Activation by Receptor Tyrosine Kinases: In Control of Cell Migration Gabi Tarcic and Yosef Yarden 8. Activation of Ras and Rho GTPases and MAP Kinases by G Protein-Coupled Receptors Mario Chiariello, Jose P. Vaqué, Piero Crespo, and J. Silvio Gutkind 9. Regulation of MAP Kinase Signaling by Calcium Colin D. White and David B. Sacks 10. Identification of Novel Substrates of MAP Kinase Cascades Using Bioengineered Kinases that Uniquely Utilize Analogs of ATP to Phosphorylate Substrates Hui Zheng, Adnan Al-Ayoubi, and Scott T. Eblen 11. ERK-MAP Kinase Signaling in the Cytoplasm Michelle C. Mendoza, Ekrem Emrah Er, and John Blenis 12. Lentiviral Vectors to Study the Differential Function of ERK1 and ERK2 MAP Kinases Marzia Indrigo, Alessandro Papale, Daniel Orellana and Riccardo Brambilla Part III: Structure-Function Relationships and Localization of MAP Kinases 13. Structural Studies of MAP Kinase Cascade Components Elizabeth J. Goldsmith, Xiaoshan Min, Haixia He, and Tianjun Zhou 14. Analysis of MAP Kinases by Hydrogen Exchange Mass Spectrometry Kevin M. Sours and Natalie G. Ahn 15. A 'Molecular Evolution' Approachfor Isolation of Intrinsically Active (MEK-Independent) MAP Kinases Vered Levin-Salomon, Oded Livnah, and David Engelberg 16. Reconstitution of the Nuclear Transport of the MAP Kinase ERK2 Arif Jivan, Aarati Ranganathan, and Melanie H. Cobb 17. Localization and Trafficking of Fluorescently Tagged ERK1 and ERK2 Matilde Marchi, Riccardo Parra, Mario Costa, and Gian Michele Ratto Part IV: Studies on the Regulation of MAP Kinase Cascades 18. Studying the Regulation of MAP Kinase by MAP Kinase Phosphatases in vitro and in Cell Systems Céline Tárrega, Caroline Nunes-Xavier, Rocío Cejudo-Marín, Jorge Martín-Pérez, and Rafael Pulido 19. Proteomic Analysis of Scaffold Proteins in the ERK Cascade Melissa M. McKay and Deborah K. Morrison 20. Analysis of ERKs' Dimerization by Electrophoresis Adán Pinto and Piero Crespo 21. MAP Kinase - SUMO Pathway Interactions Shen-Hsi Yang and Andrew D. Sharrocks 22. Computational Modelling of Kinase Signalling Cascades David Gilbert, Monika Heiner, and Rainer Breitling Part V: Use of Lower Organisms, Animal Models, and Human Genetics in the Study of MAP Kinases 23. Analysis of MAP Kinase Activity in Yeast Elaine A. Elion and Rupam Sahoo 24. Detection of RTK Pathway Activation in Drosophila Using Anti-dpERK Immunofluorescence Staining Aharon Helman and Ze'ev Paroush 25. Studying MAP Kinase Pathways During Early Development of Xenopus laevis Aviad Keren and Eyal Bengal 26. Deciphering Signaling Pathways In vivo: The Ras/Raf/Mek/Erk Cascade Gergana Galabova-Kovacs and Manuela Baccarini 27. Mutational and Functional Analysis in Human Ras/MAP Kinase Genetic Syndromes William E. Tidyman and Katherine A. Rauen Part VI: Study of MAP Kinases in Specific Physiological Systems 28. Implication of the ERK Pathway on the Post Transcriptional Regulation of VEGF mRNA Stability Khadija Essafi-Benkhadir, Jacques Pouysségur, and Gilles Pagès 29. Studies on MAP Kinase Signaling in the Immune System Hongbo Chi and
LC Classification Number
QH573-671
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- y***0 (347)- Feedback left by buyer.Past monthVerified purchaseA+++++++seller they gave me a great price and shipped it out immediately and communicated friendly. Shipping was fast and when it arrived it was packaged thoughtfully. The book is brand new and exactly as described. I have come to exect high quality books from them as they are always brand new. I definitely recommend this seller to anyone who wants beautiful books at a great price. Thank you for a great transaction.
- l***r (979)- Feedback left by buyer.Past 6 monthsVerified purchaseA Plus Seller: Transaction Good. Tested Good. Packaged Good. Better than described. Shipping reasonable time. Value contents of book: A Plus. True Life story. From one Autistic person to an other. Right on the money. Jesus Does Talk to People today. Are you listening with a Facilitator and the Spirit guiding, leading, asking Questions? I would not have believed it, until I read it. I have seen it in action. Life Change! Extremely Valuable.
- t***u (125)- Feedback left by buyer.Past 6 monthsVerified purchaseThe book was in excellent condition, quality and appearance excellent as described, and packaged safely in a box very well. Seller shipped immediately and communication and payment transfer was excellent. Great eBayer!!! Price of book was very competitive. A+++++Seed to Harvest by Octavia E. Butler (English) Paperback Book (#396114881909)