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Molecular Basis of Resilience - 9783030074609
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Item specifics
- Condition
- Book Title
- Molecular Basis of Resilience
- ISBN
- 9783030074609
- Publication Year
- 2019
- Type
- Textbook
- Format
- Paperback
- Language
- English
- Publication Name
- Molecular Basis of Resilience: Adapting to a Changing Environment
- Item Height
- 235 mm
- Publisher
- Springer Nature Switzerland A&G
- Subject
- Medicine, Biology
- Item Weight
- 686 g
- Item Width
- 155 mm
- Number of Pages
- 312 Pages
About this product
Product Information
This book illuminates mechanisms of resilience. Threats and defense systems lead to adaptive changes in gene expression. Environmental conditions may dampen adaptive responses at the level of RNA expression. The first seven chapters elaborate threats to human health. Human populations spontaneously invade niche boundaries exposing us to threats that drive the resilience process. Emerging RNA viruses are a significant threat to human health. Antiviral drugs are reviewed and how viral genomes respond to the environment driving genome sequence plasticity. Limitations in predicting the human outcome are described in nonlinear anomalies. An example includes medical countermeasures for Ebola and Marburg viruses under the Animal Rule. Bacterial infections and a review of antibacterial drugs and bacterial resilience mediated by horizontal gene transfer follow. Chapter 6 shifts focus to cancer and discovery of novel therapeutics for leukemia. The spontaneous resolution of AML in children with Down syndrome highlights human resilience. Chapter 7 explores chemicals in the environment. Examples of chemical carcinogenesis illustrate how chemicals disrupt genomes. Historic research ignored RNA damage from chemically induced nucleic acid damage. The emergence of important forms of RNA and their possible role in resilience is proposed. Chapters 8-10 discuss threat recognition and defense systems responding to improve resilience. Chapter 8 describes the immune response as a threat recognition system and response via diverse RNA expression. Oligonucleotides designed to suppress specific RNA to manipulate the immune response including exon-skipping strategies are described. Threat recognition and response by the cytochrome P450 enzymes parallels immune responses. The author proposes metabolic clearance of small molecules is a companion to the immune system. Chapter 10 highlights RNA diversity expressed from a single gene. Molecular Resilience lists paths to RNA transcriptome plasticity forms the molecular basis for resilience. Chapter 11 is an account of ExonDys 51, an approved drug for the treatment of Duchenne muscular dystrophy. Chapter 12 addresses the question what informs molecular mechanisms of resilience? that drives the limits to adaptation and boundaries for molecular resilience. He speculates that radical oxygen, epigenetic modifications, and ligands to nuclear hormone receptors play critical roles in regulating molecular resilience.
Product Identifiers
Publisher
Springer Nature Switzerland A&G
ISBN-13
9783030074609
eBay Product ID (ePID)
5046617257
Product Key Features
Number of Pages
312 Pages
Publication Name
Molecular Basis of Resilience: Adapting to a Changing Environment
Language
English
Subject
Medicine, Biology
Publication Year
2019
Type
Textbook
Format
Paperback
Dimensions
Item Height
235 mm
Item Weight
686 g
Item Width
155 mm
Additional Product Features
Country/Region of Manufacture
Switzerland
Item description from the seller
Seller business information
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- w***r (65)- Feedback left by buyer.Past 6 monthsVerified purchaseItem as described and despatched in quick time. Item arrived within 3 days and was well packaged. Item was much cheaper than I found elsewhere online. I had a query about my order and the seller responded on the same day and sorted everything out. Would happily buy from seller again
- r***y (427)- Feedback left by buyer.Past 6 monthsVerified purchaseFirst book went missing/didn't arrive, but Jessica in customer support sorted it out, sending a second copy, it arrived fast and safe, as described, well wrapped, good price and quick customer support. Thank you Jessicaππππ₯°πRunes: a Handbook - 9781783276974 (#314128475728)
- a***l (61)- Feedback left by buyer.Past 6 monthsVerified purchaseFantastic experience with this seller. I had an issue with the clay in my kit being dried out, which is something they couldn't have known about before me opening the box. I sent them a message and they replied quickly and kindly with a resolution, replacing my kit for me. Overall the kit was fantastic value and arrived brand new, in perfect condition bar the clay. Very trustworthy and helpful.
Seller Feedback (578,279)
- w***r (65)- Feedback left by buyer.Past 6 monthsVerified purchaseItem as described and despatched in quick time. Item arrived within 3 days and was well packaged. Item was much cheaper than I found elsewhere online. I had a query about my order and the seller responded on the same day and sorted everything out. Would happily buy from seller again
- r***y (427)- Feedback left by buyer.Past 6 monthsVerified purchaseFirst book went missing/didn't arrive, but Jessica in customer support sorted it out, sending a second copy, it arrived fast and safe, as described, well wrapped, good price and quick customer support. Thank you Jessicaππππ₯°πRunes: a Handbook - 9781783276974 (#314128475728)
- a***l (61)- Feedback left by buyer.Past 6 monthsVerified purchaseFantastic experience with this seller. I had an issue with the clay in my kit being dried out, which is something they couldn't have known about before me opening the box. I sent them a message and they replied quickly and kindly with a resolution, replacing my kit for me. Overall the kit was fantastic value and arrived brand new, in perfect condition bar the clay. Very trustworthy and helpful.