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Human Polyomaviruses : Molecular & Clinical Perspectives. Kamel Khalili G Stoner
£22.30
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A book that has been read, but is in good condition. Minimal damage to the book cover eg. scuff marks, but no holes or tears. If this is a hard cover, the dust jacket may be missing. Binding has minimal wear. The majority of pages are undamaged with some creasing or tearing, and pencil underlining of text, but this is minimal. No highlighting of text, no writing in the margins, and no missing pages. See the seller’s listing for full details and description of any imperfections.
- Buy it nowHuman Polyomaviruses : Molecular & Clinical Perspectives. Kamel Khalili G Stoner
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eBay item number:185432524282
Item specifics
- Condition
- Book Title
- Human Polyomaviruses : Molecular Mechanisms for Transformation an
- ISBN
- 9781606928127
- Publication Year
- 2009
- Type
- Textbook
- Format
- Paperback
- Language
- English
- Publication Name
- Human Polyomaviruses: Molecular Mechanisms for Transformation & Their Association with Cancers
- Publisher
- NOVA Science Publishers INC International Concepts
- Subject
- Medicine
- Item Weight
- 252 g
- Number of Pages
- 95 Pages
About this product
Product Information
Human polyomaviruses are non-enveloped viruses with a circular double-stranded DNA genome of approximately 5,000 base pairs. The members BK virus and JC virus were first isolated in 1971 and are very common in the human population. Simian virus 40 (SV40), although originally isolated from rhesus macaques and accidentally introduced in the human population during massive poliovirus vaccination, may represent a third member of the polyomaviruses that can have man as a natural host. Primary infection with BK or/and JC virus occurs during early childhood. Subsequently, these viruses establish a seemingly life-long harmless latent infection. However, virus reactivation can occur especially in immunocompromised individuals and JC virus has been recognised as the cause of progressive multifocal leukoencephalopathy, while BK virus-associated interstitial nephritis has become an emerging complication in renal transplant patients. The genomes of human polyomaviruses encode two functional classes of proteins: the regulatory proteins large T-antigen, small t-antigen, and agnoprotein, and the structural proteins VP1, VP2 and VP3 that form the capsid. The regulatory proteins can modulate the expression and/or activity of cellular proteins involved in signal transduction, cell cycle regulation, and chromosomal functions. Therefore, they all possess oncogenic potential. Consistent with this, human polyomaviruses are capable of transforming human cells and inducing tumours in rodents, and are implicated in human malignancies. This book focuses on the etiological role of human polyomaviruses in cancer and highlights the mechanisms by which the viral regulatory proteins may contribute to neoplastic transformation of the infected host cells. Possible therapeutic strategies against these viruses will also be discussed.
Product Identifiers
Publisher
NOVA Science Publishers INC International Concepts
ISBN-13
9781606928127
eBay Product ID (ePID)
90078191
Product Key Features
Subject
Medicine
Publication Year
2009
Number of Pages
95 Pages
Publication Name
Human Polyomaviruses: Molecular Mechanisms for Transformation & Their Association with Cancers
Language
English
Type
Textbook
Format
Paperback
Dimensions
Item Weight
252 g
Additional Product Features
Country/Region of Manufacture
United States
Item description from the seller
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